While SARM compounds share commonalities in their intended uses and modes of action, there are many differences that must be considered in your research. The list of SARMs below gives a brief description of each, you may click on the product icon for more details or purchase.
GW501516 (Cardarine or GSK-516) acts as a PPARd modulator. It activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue, and has been demonstrated to reverse metabolic abnormalities in obese subjects with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation. It has been proposed as a potential treatment for obesity and related conditions, especially when used in conjunction with a synergistic compound AICAR, as the combination has been shown to significantly increase exercise endurance in animal studies
Andarine is an agonist for androgen receptors. In an animal model of benign prostatic hypertrophy, Andarine was shown to reduce prostate weight with similar efficacy to Finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects. This suggests that it is able to block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic therapies traditionally used for treatment of BPH. Studies showed that it is rapidly absorbed and highly bioavailable after doses capable of maximal activity. The favorable pharmacokinetics of Andarine permits convenient low doses and show that it is a strong candidate for continued clinical development.